Mapping biomimicry research to sustainable development goals

Table of Contents

RQ1: SDG framework and interdisciplinary research (RQ4)

This study evaluates biomimicry research through the framework of SDGs. A cocitation SDG map shows two clusters and provides insights into the interplay between biomimicry themes and SDGs, highlighting the cross-disciplinary nature of this research (Fig. 1). The blue box hidden behind the “3 – Good Health and Well-being” and “7 – Affordable and Clean Energy” is “11 – Sustainable cities and Communities”. The blue box hidden behind “15 – Life on Land” is “16 – Peace, Justice and Strong institutions”.

Cluster 1 (Red): Biomimetic innovations for health, partnership, and life on land

This cluster comprises a diverse array of research articles that explore the application of biomimicry across various SDGs 3 (health), 17 (partnership), and 15 (land). The papers in this cluster delve into innovative biomimetic ideas, each contributing uniquely to the intersection of sustainable development and biological inspiration. SDG 3, emphasizing good health and well-being for all, is significantly represented, indicating a global effort to leverage biomimicry for advancements in healthcare, such as new medication delivery systems and medical technologies. Similarly, the frequent citations of SDG 17 underscore the vital role of partnerships in achieving sustainable growth, especially where bioinspired solutions require interdisciplinary collaboration to address complex challenges. Finally, the prominence of 15 SDG citations reflects a commitment to preserving terrestrial ecosystems, where biomimicry is increasingly applied in land management, demonstrating nature’s adaptability and resilience as a model for sustainable practices. Table 2 lists the top 5 relevant papers from Cluster 1, further illustrating the multifaceted application of biomimicry in addressing these SDGs.

Table 2 Highly cited papers in Cluster 1.

A unique binary variant of the gray wolf optimization (GWO) technique, designed especially for feature selection in classification tasks, was presented by Emary et al.⁴⁰. GWO is a method inspired by the social hierarchy and hunting behavior of gray wolves to find the best solutions to complex problems. This bioinspired optimization technique was used to optimize SDG15, which also highlights its ecological benefits. The results of the study highlight the effectiveness of binary gray wolf optimization in identifying the feature space for ideal pairings and promoting environmental sustainability and biodiversity. Lin et al.⁴¹ focused on SDG 3 by examining catalytically active nanomaterials as potential candidates for artificial enzymes. While acknowledging the limits of naturally occurring enzymes, this study explores how nanobiotechnology can address problems in the food, pharmaceutical, and agrochemical sectors.

The investigation of enzymatic nanomaterials aligns with health-related objectives, highlighting the potential for major improvements in human health. Parodi et al.⁴² used biomimetic leukocyte membranes to functionalize synthetic nanoparticles, extending biomimicry into the biomedical domain. To meet SDG 3, this research presents “leukolike vectors,” which are nanoporous silicon particles that can communicate with cells, evade the immune system, and deliver specific payloads. In line with the SDGs about health, this study emphasizes the possible uses of biomimetic structures in cancer detection and treatments. A novel strategy for biological photothermal nanodot-based anticancer therapy utilizing peptide‒porphyrin conjugate self-assembly was presented by Zou et al.⁴³. For therapeutic reasons, efficient light-to-heat conversion can be achieved by imitating the structure of biological structures. By providing a unique biomimetic approach to cancer treatment and demonstrating the potential of self-assembling biomaterials in biomedical applications, this research advances SDG 3. Finally, Wang et al.⁴⁴ presented Monarch butterfly optimization (MBO), which is a bioinspired algorithm that mimics the migration patterns of monarch butterflies to solve optimization problems effectively. This method presents a novel approach to optimization, mimicking the migration of monarch butterflies, aligning with SDG 9. Comparative analyses highlight MBO’s exceptional performance and demonstrate its capacity to address intricate issues about business and innovation, supporting objectives for long-term collaboration and sector expansion.

The publications in Cluster 1 show a wide range of biomimetic developments, from ecological optimization to new optimization techniques and biomedical applications. These varied contributions highlight how biomimicry can advance sustainable development in health, symbiosis, and terrestrial life.

Cluster 2 (green): Nature-inspired solutions for clean water, energy, and infrastructure

Cluster 2, which focuses on the innovative application of biomimicry in sustainable development, represents a range of research that aligns with SDGs 6 (sanitation), 7 (energy), 9 (infrastructure), and 14 (water). This cluster is characterized by studies that draw inspiration from natural processes and structures to offer creative solutions to sustainability-related challenges. The papers in this cluster, detailed in Table 3, demonstrate how biomimicry can address key global concerns in a varied and compelling manner.

Table 3 Highly cited papers in Cluster 2.

Within this cluster, the high citation counts for SDG 7 underscore the significance of accessible clean energy, a domain where biomimicry contributes innovative energy generation and storage solutions inspired by natural processes. This aligns with the growing emphasis on sustainable energy practices. The prominence of SDG 9 citations further highlights the global focus on innovation and sustainable industry, where biomimicry’s role in developing nature-inspired designs is crucial for building robust systems and resilient infrastructure. Furthermore, the substantial citations for SDG 6 reflect a dedicated effort toward ensuring access to clean water and sanitation for all. In this regard, biomimicry principles are being applied in water purification technologies, illustrating how sustainable solutions modeled after natural processes can effectively meet clean water objectives.

The study by Sydney Gladman et al. (2016), which presented the idea of shape-morphing systems inspired by nastic plant motions, is one notable addition to this cluster. This discovery creates new opportunities for tissue engineering, autonomous robotics, and smart textile applications by encoding composite hydrogel designs that exhibit anisotropic swelling behavior. The emphasis of SDG 9 on promoting industry, innovation, and infrastructure aligns with this biomimetic strategy. SDGs 7 and 13 are addressed in the study of Li et al.⁴⁵, which is about engineering heterogeneous semiconductors for solar water splitting. This work contributes to the goals of inexpensive, clean energy and climate action by investigating methods such as band structure engineering and bionic engineering to increase the efficiency of solar water splitting. Li et al.⁴⁶ conducted a thorough study highlighting the importance of catalysts for the selective photoreduction of CO2 into solar fuels. This review offers valuable insights into the use of semiconductor catalysts for selective photocatalytic CO2 reduction. Our work advances sustainable energy solutions by investigating biomimetic, metal-based, and metal-free cocatalysts and contributes to SDGs 7 and 13. Wang et al.⁴⁷ address the critical problem of water pollution. Creating materials with superlyophilic and superlyophobic qualities offers a creative method for effectively separating water and oil. This contributes to the goals of clean water, industry, innovation, and life below the water. It also correlates with SDGs 6, 9, and 14. Singh et al.⁴⁸ also explored the ‘green’ synthesis of metals and their oxide nanoparticles for environmental remediation, which furthers SDG 9. This review demonstrates the environmentally benign and sustainable features of green synthesis and its potential to lessen the environmental impact of conventional synthesis methods.

Cluster 2 provides nature-inspired solutions for clean water, renewable energy, and sustainable infrastructure, demonstrating the scope and importance of biomimicry. The varied applications discussed in these papers help overcome difficult problems and advance sustainable development in line with several SDGs.

RQ2: Emerging research topics

Temporal evolution of emerging topics

Figure 2 displays the publication counts for various emerging topics from 2013 to 2022, indicating growth trends over the years. For ‘Metaheuristics’, there is a notable increase in publications peaking in approximately 2020, suggesting a surge in interest. ‘Strain sensor’ research steadily increased, reaching its highest publication frequency toward the end of the period, which is indicative of growing relevance in the field. ‘Bioprinting’ sharply increased over the next decade, subsequently maintaining high interest, which highlights its sustained innovation. In contrast, ‘Actuators’ showed fluctuating publication counts, with a recent upward trend. ‘Cancer’ research, while historically a major topic, displayed a spike in publications in approximately 2018, possibly reflecting a breakthrough or increased research funding. ‘Myeloperoxidase’ has a smaller presence in the literature, with a modest peak in 2019. The number of ‘Water ‘-related publications remains relatively low but shows a slight increase, suggesting a gradual but increasing recognition of its importance. Research on exosomes has significantly advanced, particularly since 2018, signifying a greater area of focus. ‘Mechanical’ topic publications have moderate fluctuations without a clear trend, indicating steady research interest. ‘Micromotors’ experienced an initial publication surge, followed by a decline and then a recent resurgence, possibly due to new technological applications. ‘Nanogenerators’ have shown a dramatic increase in interest, particularly in recent years, while ‘Hydrogel’ publications have varied, with a recent decline, which may point toward a shift in research focus or maturity of the topic.

Figure 3 presents the distribution of various research topics based on their prominence percentile and total number of publications. Topics above the 99.9th percentile and to the right of the vertical threshold line represent the most emergent and prolific topics of study. Next, we examine the topics within each of the four quadrants, focusing on how each topic has developed over the years in relation to SDGs and the key phrases associated with each topic.

Next, we examine each research topic in four quadrants, assessing their evolution concerning SDGs. We also analyze the keyphrase cloud to identify which keyphrases are most relevant (indicated by their font size) and whether they are growing or not. In the key phrase cloud, green indicates an increasing relevance of the key phrase, grey signifies that its relevance remains constant, and blue represents a declining relevance of the key phrase.

Niche biomimetic applications

These are topics with a lower number of publications and prominence percentiles, indicating specialized or emerging areas of research that are not yet widely recognized or pursued (Quadrant 1—bottom left).

Myeloperoxidase; colorimetric; chromogenic compounds

The inclusion of myeloperoxidase indicates that inflammation and the immune system are the main research topics. The focus on chromogenic and colorimetric molecules suggests a relationship to analytical techniques for identifying biological materials. The evolution of the research is depicted in Fig. 4a shows an evolving emphasis on various sustainable development goals (SDGs) over time. The research trajectory, initially rooted in SDG 3 (Good Health and Well-being), has progressively branched out to encompass SDG 7 (Affordable and Clean Energy) and SDG 6 (Clean Water and Sanitation), reflecting an expanding scope of inquiry within the forestry sciences. More recently, the focus has transitioned toward SDG 15 (Life on Land), indicating an increased recognition of the interconnectedness between forest ecosystems and broader environmental and sustainability goals. This trend underscores the growing complexity and multidisciplinary nature of forestry research, highlighting the need to address comprehensive ecological concerns along with human well-being and sustainable development.

The word cloud in Fig. 4b highlights key phrases such as ‘Biocompatible’, ‘Actuator’, and ‘Self-healing Hydrogel’, reflecting a focus on advanced materials, while terms such as ‘Elastic Modulus’ and ‘Polymeric Networks’ suggest an emphasis on the structural properties essential for creating innovative diagnostic and environmental sensing tools. Such developments are pertinent to health monitoring and water purification, resonating with SDG 3 (Good Health and Well-being) and SDG 6 (Clean Water and Sanitation). The prominence of ‘Self-healing’ and ‘Bioinspired’ indicates a shift toward materials that emulate natural processes for durability and longevity, supporting sustainable industry practices aligned with SDG 9 (Industry, Innovation, and Infrastructure) and SDG 12 (Responsible Consumption and Production), contributing to the overarching aim of sustainable development.

Next, we analyzed the top 3 cited publications. Catalytically active nanomaterials, or nanozymes, are exciting candidates for artificial enzymes, according to Lin et al.⁴¹. The authors explore the structural features and biomimetics applications of these enzymes, classifying them as metal-, carbon-, and metal oxide-based nanomaterials. This study emphasizes the benefits of enzymes over natural enzymes, including their high stability, variable catalytic activity, and controlled production. Wang et al.⁴⁹ developed biomimetic nanoflowers made from nanozymes to cause intracellular oxidative damage in hypoxic malignancies. Under both normoxic and hypoxic conditions, the nanoflowers demonstrated catalytic efficiency. By overcoming the constraints of existing systems that depend on oxygen availability or external stimuli, this novel technique represents a viable treatment option for malignant neoplasms. Gao et al.⁵⁰ investigated the use of a dual inorganic nanozyme-catalyzed cascade reaction as a biomimetic approach for nanocatalytic tumor therapy. This approach produces a high level of therapeutic efficacy by cascading catalytic events inside the tumor microenvironment. This study highlights the potential of inorganic nanozymes for achieving high therapeutic efficacy and outstanding biosafety, which adds to the growing interest in nanocatalytic tumor therapy.

Water; hydrophobicity; aerogels

With an emphasis on hydrophobicity, aerogel use, and water-related features, this topic relates to materials science and indicates interest in cutting-edge materials with unique qualities. From Fig. 5a, we can see that, initially, the focus was directed toward SDG 6 (Clean Water and Sanitation), which is intrinsically related to the research theme, as biomimetic approaches are leveraged to develop innovative water purification and management solutions. As the research progressed, the scope expanded to intersect with SDG 14 (Life Below Water) and SDG 7 (Affordable and Clean Energy), signifying a broadened impact of biomimetic innovations in marine ecosystem conservation and energy-efficient materials. The gradual involvement with SDG 9 (industry, innovation, and infrastructure) and SDG 13 (climate action) indicates the interdisciplinary reach of this research, which aims to influence industrial practices and climate change mitigation strategies.

The word cloud in Fig. 5b reinforces this narrative by showcasing key phrases such as ‘Hydrophobic’, ‘Bioinspired’, ‘Emulsion’, and ‘Oil Pollution’, which reflect the emphasis on developing materials and technologies that mimic natural water repellency and separation processes. ‘Aerogel’ and ‘polydopamine’, along with ‘Underwater’ and ‘Biomimetic Cleaning’, suggest a strong focus on creating lightweight, efficient materials capable of self-cleaning and oil spill remediation. These keywords encapsulate the essence of the research theme, demonstrating a clear alignment with the targeted SDGs and the overall aim of sustainable development through biomimicry.

Three highly referenced works that have made substantial contributions to the field of biomimetic materials for oil/water separation are included in the table. The development of superlyophilic and superlyophobic materials for effective oil/water separation was examined by Wang et al.⁴⁷. This review highlights the applications of these materials in separating different oil-and-water combinations by classifying them according to their surface wettability qualities. The excellent efficiency, selectivity, and recyclability of the materials—which present a viable treatment option for industrial oily wastewater and oil spills—are highlighted in the paper. Su et al.⁵¹ explored the evolution of super wettability systems. The studies included superhydrophobicity, superoleophobicity, and undersea counterparts, among other extreme wettabilities. The kinetics, material structures, and wetting conditions related to obtaining superwettability are covered in the article. This demonstrates the wide range of uses for these materials in chemistry and materials science, including self-cleaning fabrics and systems for separating oil and water. Zhang et al.⁵² presented a bioinspired multifunctional foam with self-cleaning and oil/water separation capabilities. To construct a polyurethane foam with superhydrophobicity and superoleophobicity, this study used porous biomaterials and superhydrophobic self-cleaning lotus leaves. Foam works well for separating oil from water because of its slight weight and ability to float on water. It also shows exceptional resistance to corrosive liquids. According to the article, multifunctional foams for large-scale oil spill cleaning might be designed using a low-cost fabrication technology that could be widely adopted.

Growing interest in bioinspired healthcare

These topics have a higher prominence percentile but a lower number of publications, suggesting growing interest and importance in the field despite a smaller body of research (Quadrant 2—top left).

Exosomes; extracellular vesicles; MicroRNAs

Exosomes and extracellular vesicles are essential for intercellular communication, and reference to microRNAs implies a focus on genetic regulation. The evolution of this topic reflects an increasing alignment with specific sustainable development goals (SDGs) over the years. The initial research focused on SDG 3 (good health and well-being) has expanded to encompass SDG 9 (industry, innovation, and infrastructure) and SDG 6 (clean water and sanitation), showcasing the multifaceted impact of biomimetic research in healthcare (Fig. 6a). The research trajectory into SDG 9 and SDG 6 suggests broader application of bioinspired technologies beyond healthcare, potentially influencing sustainable industrial processes and water treatment technologies, respectively.

The word cloud (Fig. 6b) underscores the central role of ‘Extracellular Vesicles’ and ‘Exosomes’ as platforms for ‘Targeted Drug Delivery’ and ‘Nanocarrier’ systems, which are key innovations in medical biotechnology. The prominence of terms such as ‘Bioinspired’, ‘Biomimetic’, ‘Liposome’, and ‘Gold Nanoparticle’ illustrates the inspiration drawn from biological systems for developing advanced materials and delivery mechanisms. These key phrases indicate significant advancements in ‘Controlled Drug Delivery Systems’, ‘Cancer Chemotherapy’, and ‘Molecular Imaging’, which have contributed to improved diagnostics and treatment options, consistent with the objectives of SDG 3.

The work by Jang et al.⁵³, which introduced bioinspired exosome-mimetic nanovesicles for improved drug delivery to tumor tissues, is one of the most cited articles. These nanovesicles, which resemble exosomes but have higher creation yields, target cells and slow the growth of tumors in a promising way. Yong et al.’s⁵⁴ work presented an effective drug carrier for targeted cancer chemotherapy, focusing on biocompatible tumor cell-exocytosed exosome-biomimetic porous silicon nanoparticles. A paper by Cheng et al.⁵⁵ discussed the difficulties in delivering proteins intracellularly. This study suggested a biomimetic nanoparticle platform that uses extracellular vesicle membranes and metal–organic frameworks. These highly cited studies highlight the importance of biomimetic techniques in improving drug delivery systems for improved therapeutic interventions.

Nanogenerators; piezoelectric; energy harvesting

This topic advises concentrating on technology for energy harvesting, especially for those that use piezoelectric materials and nanogenerators. We see a rising focus on medical applications of biomimetics, from diagnostics to energy harvesting mimicking biological systems.

The evolution of this research topic reflects a broader contribution to the SDGs by not only addressing healthcare needs but also by promoting sustainable energy practices and supporting resilient infrastructure through biomimetic innovation (Fig. 7a). Initially, the emphasis on SDG 3 (Good Health and Well-being) suggested the early application of biomimetic principles in healthcare, particularly in medical devices and diagnostics leveraging piezoelectric effects. Over time, the transition toward SDG 7 (Affordable and Clean Energy) and SDG 9 (Industry, Innovation, and Infrastructure) indicates an expansion of bioinspired technologies into sustainable energy solutions and industrial applications. Nanogenerators and energy harvesting techniques draw inspiration from biological processes and structures, aiming to optimize energy efficiency and contribute to clean energy initiatives.

The word cloud in Fig. 7b emphasizes key phrases such as ‘Piezoelectric’, ‘Energy Harvesting’, ‘Tactile Sensor’, ‘Triboelectricity’, and ‘Nanogenerators’, highlighting the core technologies that are being developed. These terms, along with ‘Bioinspired’, ‘Wearable Electronic Devices’, and ‘Energy Conversion Efficiency’, illustrate the convergence of natural principles with advanced material science to create innovative solutions for energy generation and sensor technology.

Yang et al.’s⁵⁶ study in Advanced Materials presented the first triboelectrification-based bionic membrane sensor. Wearable medical monitoring and biometric authentication systems will find new uses for this sensor since it allows self-powered physiological and behavioral measurements, such as noninvasive human health evaluation, anti-interference throat voice recording, and multimodal biometric authentication. A thorough analysis of the state-of-the-art in piezoelectric energy harvesting was presented by Sezer and Koç⁵⁷. This article addresses the fundamentals, components, and uses of piezoelectric generators, highlighting their development, drawbacks, and prospects. It also predicts a time when piezoelectric technology will power many electronics. The 2021 paper by Zhao et al.⁵⁸ examines the use of cellulose-based materials in flexible electronics. This section describes the benefits of these materials and the latest developments in intelligent electronic device creation, including biomimetic electronic skins, optoelectronics, sensors, and optoelectronic devices. This review sheds light on the possible drawbacks and opportunities for wearable technology and bioelectronic systems based on cellulose.

Leading edge of biomimetic sensing and electronics

This quadrant represents topics with both a high number of publications and a prominence percentile, indicating well-established and influential research areas (Quadrant 3—top right).

Strain sensor; flexible electronics; sensor

Figure 8a highlights the progress of research on bioinspired innovations, particularly in the development of strain sensors and flexible electronics for adaptive sensing technologies. Initially, concentrated on health applications aligned with SDG 3 (Good Health and Well-being), the focus has expanded. The integration of SDG 9 (Industry, Innovation, and Infrastructure) indicates a shift toward industrial applications, while the incorporation of SDG 7 (Affordable and Clean Energy) suggests a commitment to energy-efficient solutions. Additionally, the mention of SDG 11 (Sustainable Cities and Communities) and SDG 12 (Responsible Consumption and Production) reflects the broadening scope to include urban sustainability and eco-friendly manufacturing practices.

Figure 8b provides insight into the key phrases associated with this research topic, highlighting terms such as ‘Bioinspired’, ‘Self-healing’, ‘Wearable Electronic Devices’, ‘Flexible Electronics’, and ‘Pressure Sensor’. These key phrases speak to the innovative approaches for creating sensors and electronics that are not only inspired by biological systems but also capable of seamlessly integrating human activity and environmental needs. The mention of ‘Wearable Sensors’ and ‘Tactile Sensor’ indicates a focus on user interaction and sensitivity, which is crucial for medical applications and smart infrastructure.

The top three articles with the most citations represent the cutting edge of this topic’s study. Chortos et al.⁵⁹ investigated how skin characteristics can be replicated for medicinal and prosthetic uses. Kim et al.⁶⁰ focused on creating ultrathin silicon nanoribbon sensors for smart prosthetic skin, opening up new possibilities for bionic systems with many sensors. A bioinspired microhairy sensor for ultraconformability on nonflat surfaces was introduced in Pang et al.’s⁶¹ article, which significantly improved signal-to-noise ratios for accurate physiological measurements.

Cancer; photoacoustics; theranostic nanomedicine

Modern technologies such as photoacoustics, theranostic nanomedicine, and cancer research suggest that novel cancer diagnosis and therapy methods are highly needed. Figure 9a traces the research focus that has evolved across various SDGs over time, commencing with SDG 3 (Good Health and Well-being), which is indicative of the central role of health in biomimetic research. It then extends into SDG 9 (Industry, Innovation, and Infrastructure) and SDG 7 (Affordable and Clean Energy), illustrating the cross-disciplinary applications of biomimetic technologies from healthcare to the energy and industrial sectors.

Figure 9b provides a snapshot of the prominent keywords within this research theme, featuring terms such as “photodynamic therapy”, “photothermal chemotherapy”, “nanocarrier”, and “controlled drug delivery”. These terms underscore the innovative therapeutic strategies that mimic biological mechanisms for targeted cancer treatment. ‘Bioinspired’ and ‘Biomimetic Synthesis’ reflect the approach of deriving design principles from natural systems for the development of advanced materials and medical devices. ‘Theranostic nanomedicine’ integrates diagnosis and therapy, demonstrating a trend toward personalized and precision medicine.

A study conducted by Yu et al.⁶² presented a novel approach for synergistic chemiexcited photodynamic-starvation therapy against metastatic tumors: a biomimetic nanoreactor, or bio-NR. Bio-NRs use hollow mesoporous silica nanoparticles to catalyze the conversion of glucose to hydrogen peroxide for starvation therapy while also producing singlet oxygen for photodynamic therapy. Bio-NR is promising for treating cancer metastasis because its coating on cancer cells improves its biological qualities. Yang et al.’s⁶³ study focused on a biocompatible Gd-integrated CuS nanotheranostic agent created via a biomimetic approach. This drug has low systemic side effects and good photothermal conversion efficiency, making it suitable for skin cancer therapy. It also performs well in imaging. The ultrasmall copper sulfide nanoparticles generated within ferritin nanocages are described in Wang et al.’s⁶⁴ publication. This work highlights the possibility of photoacoustic imaging-guided photothermal therapy with improved therapeutic efficiency and biocompatibility. These highly referenced articles highlight the significance of biomimetic techniques in furthering nanotheranostics and cancer therapy.

Established biomimetic foundations

Here, there are topics with a greater number of publications but a lower prominence percentile, which may imply areas where there has been significant research but that may be waning in influence or undergoing a shift in focus (Quadrant 4—bottom right).

Metaheuristics; Fireflies; Chiroptera

This topic is a fascinating mix of subjects. Using Firefly and Chiroptera in metaheuristic optimization algorithms provides a bioinspired method for resolving challenging issues. The thematic progression of research papers suggests the maturation of biomimetic disciplines that resonate with several SDGs (Fig. 10a). The shift from initially aligning with SDG 3 (Good Health and Well-being) extends to intersecting with goals such as SDG 9 (Industry, Innovation, and Infrastructure), SDG 7 (Affordable and Clean Energy), SDG 11 (Sustainable Cities and Communities), SDG 13 (Climate Action), and SDG 15 (Life on Land). This diversification reflects the expansive utility of biomimetic approaches, from health applications to broader environmental and societal challenges.

The top keyphrases, such as ‘Swarm Intelligence’, ‘Global Optimization’, ‘Cuckoo Search Algorithm’, and ‘Particle Swarm Optimization’, are shown in Fig. 10b highlights the utilization of nature-inspired algorithms for solving complex optimization problems. These terms, along with the ‘Firefly Algorithm’ and ‘Bat Algorithm’, underscore the transition of natural phenomena into computational algorithms that mimic the behavioral patterns of biological organisms, offering robust solutions in various fields, including resource management, logistics, and engineering design.

The three highly referenced metaheuristic publications centered around the “Moth Flame Optimization (MFO),” Salp Swarm Algorithm (SSA),” and Whale Optimization Algorithm (WOA).” The WOA, authored by Mirjalili and Lewis⁶⁵, is a competitive solution for mathematical optimization and structural design issues because it emulates the social behavior of humpback whales. Inspired by the swarming behavior of salps, Mirjalili et al.⁶⁶ introduced the SSA and multiobjective SSA. This shows how well they function in optimizing a variety of engineering design difficulties. Finally, Mirjalili⁶⁷ suggested the MFO algorithm, which is modeled after the navigational strategy of moths and exhibits competitive performance in resolving benchmark and real-world engineering issues.

Bioprinting; three-dimensional printing; tissue engineering

The emphasis on sophisticated manufacturing methods for biological applications in this field suggests a keen interest in the nexus of biology and technology, especially in tissue engineering. As shown in Fig. 11a, the topic’s evolution encompasses Sustainable Development Goals (SDGs) that have transitioned over the years, including SDG 3 (Good Health and Well-being), which is inherently connected to the advancement of medical technologies and tissue engineering for health applications. This research also touches upon SDG 6 (Clean Water and Sanitation) and SDG 7 (Affordable and Clean Energy), suggesting applications of bioprinting technologies in the environmental sustainability and energy sectors. The progression toward SDG 9 (Industry, Innovation, and Infrastructure) and SDG 15 (Life on Land) reflects a broader impact, where biomimetic principles are applied to foster innovation in industrial processes and contribute to the preservation of terrestrial ecosystems.

Key phrases emerging from the word cloud in Fig. 11b, such as “Hydrogel”, “Biofabrication”, “Tissue Scaffold”, and “Regenerative Medicine”, highlight the specialized methodologies and materials that are inspired by natural processes and structures. Terms such as ‘Three-Dimensional Printing’ and ‘Bioprinting’ underscore the technological advancements in creating complex biological structures, aiming to revolutionize the field of tissue engineering and regenerative medicine.

Three widely referenced papers about advances in 3D printing—particularly in bioprinting, soft matter, and the incorporation of biological tissue with functional electronics—are described next. Truby and Lewis’s⁶⁸ review of light- and ink-based 3D printing techniques is ground-breaking. This highlights the technology’s capacity to create soft matter with tunable properties and its potential applications in robotics, shape-morphing systems, biologically inspired composites, and soft sensors. Ozbolat, and Hospodiuk⁶⁹ provide a thorough analysis of “extrusion-based bioprinting (EBB).” The adaptability of EBB in printing different biologics is discussed in the paper, with a focus on its uses in pharmaceutics, primary research, and clinical contexts. Future directions and challenges in EBB technology are also discussed. Using 3D printing, Mannoor et al.⁷⁰ presented a novel method for fusing organic tissue with functioning electronics. In the proof-of-concept, a hydrogel matrix seeded with cells and an interwoven conductive polymer containing silver nanoparticles are 3D printed to create a bionic ear. The improved auditory sensing capabilities of the printed ear show how this novel technology allows biological and nanoelectronic features to work together harmoniously.

RQ3: Translation and commercialization

Biomimicry offers promising solutions for sustainability in commercial industries with environmentally sustainable product innovation and energy savings with reduced resource commitment⁷¹. However, translating biomimicry innovations from research to commercialization presents challenges, including product validation, regulatory hurdles, and the need for strategic investment, innovative financial models, and interdisciplinary collaboration^71,72,73,74. Ethical considerations highlight the need for universally applicable ethical guidelines regarding the moral debates surrounding biomimicry, such as motivations for pursuing such approaches and the valuation of nature⁷⁵.

Addressing these barriers requires interdisciplinary collaboration, targeted education, and training programs. Strategic investment in biomimicry research and development is also crucial. Encouraging an engineering mindset that integrates biomimicry principles into conventional practices and developing commercial acumen among researchers is essential for navigating the market landscape⁷⁶. Securing sufficient funding is essential for the development, testing, and scaling of these innovations⁷⁶.

Successful case studies illustrate that the strategic integration of biomimicry enhances corporate sustainability and innovation (Larson & Meier 2017). In biomedical research, biomimetic approaches such as novel scaffolds and artificial skins have made significant strides (Zhang 2012). Architecture benefits through energy-efficient building facades modeled after natural cooling systems (Webb et al. 2017). The textile industry uses biomimicry to create sustainable, high-performance fabrics⁷⁷.

RQ4: Interdisciplinary collaboration

Agricultural innovations (SDGs 1—No poverty and 2—Zero hunger)

Environmental degradation, biodiversity loss, poverty, and hunger highlight the need for sustainable agricultural methods to mimic natural ecosystems. This includes computational models for ecological interactions, field experiments for biomimetic techniques, and novel materials inspired by natural soil processes. Research can develop solutions such as artificial photosynthesis for energy capture, polyculture systems mimicking ecosystem diversity, and bioinspired materials for soil regeneration and water retention²⁸. These innovations can improve sustainability and energy efficiency in agriculture, addressing poverty and hunger through sustainable farming practices.

Educational models (SDG 4—Quality education)

Integrating sustainability principles and biomimicry into educational curricula at all levels presents opportunities for innovation. Collaborations between educators, environmental scientists, and designers can create immersive learning experiences that promote sustainability. This includes interdisciplinary curricula with biomimicry case studies, digital tools, and simulations for exploring biomimetic designs, and participatory learning approaches for engaging students with natural environments. Designing biomimicry-based educational tools and programs can help students engage in hands-on, project-based learning¹⁰, fostering a deeper understanding of sustainable living and problem-solving.

Gender-inclusive design (SDG 5—Gender inequality)

Gender biases in design and innovation call for research into biomimetic designs and technologies that facilitate gender equality. This includes participatory design processes involving women as cocreators, studying natural systems for inclusive strategies, and applying biomimetic principles to develop technologies supporting gender equality. Bioinspired technologies can address women’s specific needs, enhancing access to education, healthcare, and economic opportunities. Interdisciplinary approaches involving gender studies, engineering, and environmental science can uncover new pathways for inclusive innovation.

Inclusive urban solutions (SDG 11—Sustainable cities and communities)

Rapid urbanization challenges such as housing shortages, environmental degradation, and unsustainable transportation systems require innovative solutions. Methodologies include systems thinking in urban planning, simulation tools for modeling biomimetic solutions, and pilot projects testing bioinspired urban innovations. Research on biomimetic architecture for affordable housing, green infrastructure for climate resilience, and bioinspired transportation systems can offer solutions. Collaborative efforts among architects, urban planners, ecologists, and sociologists are essential⁷⁸.

Peace and justice (SDG 16—Peace, justice and institutions)

Social conflicts and weak institutions necessitate innovative approaches that integrate political science, sociology, and biology. Methods involve case studies, theoretical modeling, and participatory action research to develop strategies for peacebuilding and institutional development.

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Mapping biomimicry research to sustainable development goals

RQ1: SDG framework and interdisciplinary research (RQ4)

Cluster 1 (Red): Biomimetic innovations for health, partnership, and life on land